HPE launches ProLiant servers with new NVIDIA GPUs for AI growth
HPE has announced new developments to its NVIDIA AI Computing by HPE Portfolio, focusing on improved integration with NVIDIA AI Enterprise and the introduction of updated NVIDIA AI models and blueprints to HPE Private Cloud AI.
Server enhancements
HPE will offer HPE ProLiant Compute servers equipped with NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs, introducing a 2U form factor designed to meet the rising AI demands within enterprise data centres.
According to the announcement, two main server configurations will be available. The HPE ProLiant DL385 Gen11 server supports up to two NVIDIA RTX PRO 6000 Blackwell GPUs in the new 2U form factor. The HPE ProLiant Compute DL380a Gen12 server supports up to eight NVIDIA RTX PRO 6000 GPUs in a 4U form factor and is scheduled to ship in September.
These servers are intended to support diverse workloads, from generative and agentic AI to physical AI use cases, which include robotics, industrial automation, visual computing, and simulation.
HPE highlights that its Gen12 ProLiant Compute servers employ multi-layered security, using HPE Integrated Lights Out (iLO) 7 Silicon Root of Trust and a secure enclave to deliver tamper-resistant protection and quantum-resistant firmware signing.
Lifecycle automation is managed through HPE Compute Ops Management, which, the company states, can reduce IT hours for server management by up to 75% and decrease downtime by an average of 4.8 hours per server annually.
The servers are positioned to address escalating enterprise requirements for GPU-accelerated compute power, offering flexibility to innovate and enhance productivity, security, and operational efficiency across enterprise operations.
Private cloud AI advancements
The company recently shared details about the upcoming generation of HPE Private Cloud AI, expected to be released later in the year.
This expansion supports NVIDIA RTX PRO 6000 GPUs, enables scalability across GPU generations, and provides features like air-gapped management and enterprise multi-tenancy.
HPE Private Cloud AI, co-developed with NVIDIA, will add support for the latest NVIDIA Nemotron models for agentic AI, Cosmos Reason vision language model for physical AI and robotics, and NVIDIA's Blueprint for Video Search and Summarisation (VSS 2.4).
These features are designed to assist customers in building video analytics AI agents capable of analysing large volumes of video data for valuable insights.
The company emphasises the continuous co-development between HPE and NVIDIA in order to facilitate the fastest deployment of NVIDIA NIM microservices for the latest AI models and blueprints. Customers can access these features via HPE AI Essentials.
The overall aim is to provide enterprises with the infrastructure needed to address increasing demand for AI inferencing and accelerate the production of AI solutions, while ensuring data control and high-performance operation.
Industry perspectives
"HPE is committed to empowering enterprises with the tools they need to succeed in the age of AI," said Cheri Williams, Senior Vice President and General Manager for Private Cloud and Flex Solutions at HPE.
"Our collaboration with NVIDIA continues to push the boundaries of innovation, delivering solutions that unlock the value of generative, agentic and physical AI while addressing the unique demands of enterprise workloads. With the combination of HPE ProLiant servers and expanded capabilities in HPE Private Cloud AI, we're enabling organisations to embrace the future of AI with confidence and agility."
Justin Boitano, Vice President of Enterprise AI at NVIDIA, commented on the server integration, stating: "Enterprises need flexible, efficient infrastructure to keep pace with the demands of modern AI."
"With NVIDIA RTX PRO 6000 Blackwell GPUs in HPE's 2U ProLiant servers, enterprises can accelerate virtually every workload on a single, unified, enterprise-ready platform."
Release schedule
The HPE ProLiant DL385 Gen11 and HPE ProLiant Compute DL380a Gen12 servers featuring NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs are available to order now, with shipping scheduled to begin globally in September 2025.
Support for NVIDIA Nemotron models, Cosmos Reason, and NVIDIA VSS 2.4 Blueprint within HPE Private Cloud AI is planned for the second half of 2025.
The latest generation of HPE Private Cloud AI with RTX PRO 6000 Blackwell GPUs will also be available in the latter part of the year.
